Based on a landmark study conducted by the National Institute of Mental Health, up to 70% of all patients can expect significant relief after a series of six ketamine infusions. We have found that by curating the patient experience, providing an exceptional level of support, and setting realistic expectations, we consistently see outcome metrics that outperform the NIMH study.

It is important to understand that it is impossible to predict an outcome for a specific patient. Thankfully, owing to the ease and accessibility of treatment and the absence of known side-effects, it is possible to explore the benefits of therapy without risk.

Initially, all patients receive a series of six infusions spaced over two or three weeks. This follows the protocol developed during the NIMH trial and is the best predictor of efficacy. Ketamine is administered over a period of 40 minutes. The dose is determined by your weight. The amount of ketamine administered is not enough to cause a loss of consciousness, so you will remain awake.

During the infusion, some patients experience a waking dream-like state or mild euphoria. Most find the treatment very pleasant. Patients generally leave the office within a few minutes following the infusion and feel quite normal. It is important not to drive, operate any dangerous machinery, or make any important decisions until the day after a ketamine infusion, as reaction times can be significantly diminished immediately following the infusion.

Some patients seem to achieve long-term relief after the initial series of six infusions, and others require additional infusions at varying frequencies to maintain relief. Aftercare is an essential part of ketamine therapy, and Dr. Curro will work with you to determine the best approach for you to achieve lasting relief.

A very small percentage of patients begin to feel better within hours of the first infusion. Patients with thoughts of self-harm often notice those thoughts dissipating first with a dramatic relief of dread and hopelessness. Many patients do not notice a significant mood improvement until they’ve had several infusions. Almost all patients who will respond feel measurably better after the series of six infusions.

IV Ketamine therapy that follows the NIMH protocol results in no known long-term side effects. The bioavailability of ketamine delivered intravenously is far superior to any other form of administration. This means that a much smaller dosage yields a superior result. Other forms of ketamine are significantly less effective and likely to produce side effects.

You should not make any adjustments to your current medications without specific approval from the prescriber. It is important to note that while there is some speculation related to benzodiazepine and lamotrigine and their effect on ketamine infusions, there is no actual evidence to support adjustments in either in advance of therapy. While these medications may reduce the dissociative effects of ketamine during an infusion, our experience suggests that they have no negative impact on outcomes.

Because IV ketamine therapy for mood and anxiety disorders is off-label, insurance companies do not provide reimbursement. Thankfully, IV ketamine therapy is not only the most effective treatment, but it is also the least expensive.